By James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith
History, Wild Mice, and Genetics, the 1st quantity within the 4 quantity set, The Mouse in Biomedical Research, offers information regarding the historical past, biology and genomics of the laboratory mouse (Mus musculus), in addition to simple info on upkeep and use of mouse shares. Mouse origins and relationships are lined in chapters on historical past, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are coated in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular association of the mouse genome. upkeep of laboratory mice is defined in chapters on breeding structures for numerous varieties of traces and shares and genetic tracking. Use of the mouse as a version method for easy biomedical examine is defined in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. the data in quantity 1 serves as a primer for scientists new to the sphere of mouse learn.
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Additional info for The Mouse in Biomedical Research. History, Wild Mice, and Genetics
This brings us to milestone 10: the sequencing of the mouse genome. Two sets of investigators were responsible for this achievement, which came just one year after completion of the human genome sequencing effortmthe public Mouse Genome Sequencing Consortium (MGSC) and Celera. The Celera sequence of a mixed mouse genome from five inbred strains was published in May 2001, and the full draft sequence of the C57BL/6 mouse was completed in December of 2002 by the MGSC. Thus, between 1902 and 2002, the mouse genetic community had passaged from the first demonstration of Mendelism to establishing the ultimate physical genetic map.
INTRODUCTION Research on model organisms, like the mouse, often is justified based on the assumption that discoveries can be generalized to other organisms (Kellogg and Shaffer 1993). An understanding of the significance of one's findings, however, requires a comparative context. , mouse and human), or are they unique to a single species or even a single population? Comparative studies require a THE MOUSE IN BIOMEDICAL RESEARCH, 2ND EDITION 13 14 14 14 14 15 16 16 16 17 19 19 19 19 21 21 21 phylogenetic or historical framework in which to determine, for example, whether genes, genetic or developmental pathways, physiological features, or complex traits are similar across organisms due to common ancestry or due to convergence.
Soc. 30, 51-58. , Moriwaki, K. (1989). Genetical variation and polyphyletic origin in Japanese Mus musculus. Heredity 63, 299-308. , Boursot, E (1994). The mouse as a ring species? In Genetics in wild mice. Its application to biomedical research, K. Moriwaki, T. Shiroishi, H. , 13-23. Japan Scientific Societies Press, Tokyo and Karger, Basel. , Bonhomme, E (1993). The evolution of house mice. Annu. Rev. Ecol. Syst. 24, 119-152. , Von Deimling, E et al. (1996). Origin and radiation of the house mouse: Mitochondrial DNA phylogeny.
The Mouse in Biomedical Research. History, Wild Mice, and Genetics by James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith