New PDF release: Competing Risks: A Practical Perspective

By Melania Pintilie

ISBN-10: 0470870680

ISBN-13: 9780470870686

The necessity to comprehend, interpret and examine competing danger info is vital to many parts of technological know-how, relatively clinical learn. there's a actual desire for a e-book that provides an summary of technique utilized in the translation and research of competing hazards, with a spotlight on useful functions to scientific difficulties, and incorporating glossy options. This ebook fills that want by way of providing the main up to date method, in a manner that may be comfortably understood, and utilized, by way of the practitioner.

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Extra info for Competing Risks: A Practical Perspective

Sample text

In this case the observation of distant disease hinders the observation of local disease. Furthermore, the occurrence of local disease after distant disease may not be of much interest since treatment of the distant disease may alter the chances of local disease recurring. More generally, the term ‘relapse’ refers to the return or recurrence of any potentially chronic condition or disease after an initial improvement. For instance, in studies of smoking cessation, relapse refers to the resumption of the previous smoking behaviour.

Since many of these descriptions shed light on different aspects of the competing risks situation, several are presented here in order to best illustrate the point. Kalbfleisch and Prentice (2002) described competing risks as the situation in which an individual can experience more than one type of event. Gelman et al. (1990) and Caplan et al. (1994) explain it as the failure to achieve independence between the time to an event and the censoring mechanism. And finally, Gooley et al. (1999) defined the concept of competing risks as the situation where one type of event ‘either precludes the occurrence of another event under investigation or fundamentally alters the probability of occurrence of this other event’.

In this case, the subhazard is defined first and the CIF does not have a closed form (Crowder, 2001). 2 were chosen because they have relatively simple mathematical forms and have appeared in the literature as providing reasonable models for many cases of competing risks data. 5) 0 The subdistribution function represents the probability of an event of type i happening by time t. 7) and in the case where the p latent times are statistically independent, it is identical to the subhazard. 3 the cause-specific hazard is the same as the subhazard except for the second example where the cause-specific hazard is still 1 as for the independent case.

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Competing Risks: A Practical Perspective by Melania Pintilie

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