By JoAnn E. Manson, Julie E. Buring, Paul M. Ridker, J. Michael Gaziano
This new version covers vital new trials in cardiology remedies and prevention of cardiovascular difficulties. the area gurus on pharmacologic medical trials write concerning the trials, the results and significance for medical practice.This booklet offers the overall heart specialist perception into the advance of recent treatments in cardiology in addition to the method of ways trials have been used for these remedies. as well as supplying a guide for the way to set up trials, trials for remedy and prevention are covered.Evidence-based examine to steer scientific practice.Coverage of therapy trials together with Glycoprotein IIb/IIa receptor inhibitors, aspirin, drug cures for arrhythmias, and pacing.Expanded part on prevention of cardiac diseaseCovers either prevention and treatment.Data and defense tracking forums in Randomized TrialsCoronary Artery pass SurgeryImplantable Cardioverter-Defibrillators and Cardiac Resynchronization TherapyPostmenopausal Hormone treatment
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Additional resources for Clinical Trials in Heart Disease: A Companion to Braunwald's Heart Disease
This competing risk may affect the ascertainment of the primary outcomes of interest. , blood pressure) as the outcome, the duration is directly related to the research question in that some research questions specifically address the shorter- or longer-term effects of the intervention. A distinction between studies of efficacy and effectiveness is sometimes made. An efficacy trial is one in which a well-controlled intervention is assessed under optimal circumstances with high compliance to ask how beneficial (or harmful) the regimen or procedure is itself.
Although the number of hemorrhagic strokes was small, and the event rate was much lower than that of nonfatal infarctions, the consequences of a hemorrhagic stroke were nonetheless worrisome. As a further complication, aspirin was already approved as a secondary prevention for cardiovascular mortality in an MI population, and PHS physicians who had an MI during the trial began taking aspirin as a preventive measure. This further decreased the likelihood of detecting any aspirin effect on mortality.
49. Mayer JP, Hawkins B,Todd R: A randomized evaluation of smoking cessation interventions for pregnant women at a WIC clinic. Am J Public Health 1990; 80:76–78. 50. Yusuf S, Zucker D, Peduzzi P, et al: Effect of coronary artery bypass graft surgery on survival: Overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration. Lancet 1994; 344:563–570. 51. Kelsey SF: Strategies for statistical analysis of angiographic data: Individual lesions versus individual patients.
Clinical Trials in Heart Disease: A Companion to Braunwald's Heart Disease by JoAnn E. Manson, Julie E. Buring, Paul M. Ridker, J. Michael Gaziano