By P. Palange, S. Ward
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Extra resources for Clinical Exercise and Testing (European Respiratory Monograph)
Dual role of diffusion in tissue gas exchange: blood tissue equilibration and diffusion shunt. Respir Physiol 1984; 56: 131–144. Wagner PD. Counterpoint: in health and in normoxic environment V9O2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol 2006; 100: 745–747. West JB, Wagner PD. Pulmonary gas exchange. In: West JB, ed. Bioengineering Aspects of the Lung. New York, Dekker, 1977, pp. 361–394. Hansen JE, Sue DY, Wasserman K. Predicted values for clinical exercise testing.
Physiol Rev 1977; 57: 779–815. Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE, Cobb FR. Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res 1986; 58: 281–291. Rowell LB. Human Cardiovascular Control. New York, Oxford University Press, 1993. Janicki JS, Sheriff DD, Robotham JL, Wise RA. Cardiac output during exercise: contributions of the cardiac, circulatory and respiratory systems. In: Rowell LB, Shepherd JT, eds. Handbook of Physiology.
In the simplest form, this means that the instantaneous rate of change of the particular variable will be proportional to the distance from the steady state. The time to attain a steady state naturally depends upon the rate at which this exponential response develops. This is conventionally characterised with respect to the time constant (t) of the response. For such an exponential response, this is the time for the variable to attain 63% of the final steady-state change. e. the function will have attained 99% of its steady-state value, which is well within current levels of discriminability.
Clinical Exercise and Testing (European Respiratory Monograph) by P. Palange, S. Ward