Amy Odegard, Manidipa Banerjee, John E. Johnson (auth.),'s Cell entry by non-enveloped viruses PDF

By Amy Odegard, Manidipa Banerjee, John E. Johnson (auth.), John E. Johnson (eds.)

ISBN-10: 3642133320

ISBN-13: 9783642133329

Non enveloped viruses represent a huge classification of medically major pathogens. They encode their proteins in unmarried (ss) and double strand (ds) RNA and DNA genomes and reveal numerous sizes and constructions. during this quantity specialists within the box supply brand new descriptions of many features linked to the ssRNA noda, picorna and calciviruses, the dsRNA reo and rotaviruses, the ssDNA parvoviruses and the dsDNA polyoma and adenoviruses. whereas many features of those viruses were addressed formerly, this quantity in particular makes a speciality of the difficulty in their access into cells, with specific recognition to the translocation of the viral genome via a membrane, with no the help of inter-membrane fusion that's universal and fairly good understood in enveloped viruses. adequate element has been printed in many of the viruses mentioned during this quantity to set up a reputable argument for convergent evolution. various mechanisms are defined to generate and tightly regulate the publicity of a fusion-like peptide or a whole gene product that allows membrane permeation and genome supply into the cytoplasm and, for the DNA viruses, the nucleus. on the grounds that there's no viral membrane to fuse with the mobile membrane, the occasions at this interface are diverse from these linked to enveloped viruses and with a number of the fusion occasions linked to basic mobile functionality. therefore, whereas the criteria serious for this procedure to take place were good verified for lots of of those viruses, a particular mechanism for genome penetration is but to be made up our minds. We think that this quantity will offer a reference of tolerating price for the non enveloped virus box and our wish is that the point of interest on access and genome translocation throughout a mobile membrane will stimulate new principles and mechanistic reviews of this seriously very important process.

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The biological role of this “enlarged” state of MNV is still unclear but the availability of an animal model, a cell culture system, and an infectious clone make its elucidation a tractable problem for further study. 7 The Cryo-TEM Structure of MNV-1 Complexed with Fab’s The only other image reconstruction of an antibody bound to a Calicivirus was that of RHDV VLP complexed with whole antibody as reviewed above (Thouvenin et al. 1997). 2/MNV-1 complex (Fig. 4) was determined using cryo-TEM methods (Katpally et al.

1999) where the ribbons are colored blue to red as the chain extends from the amino to carboxyl termini between the domains of VP1 that likely impacts the relative orientation of the domains. As shown in Fig. 1, the P1/P2 domains in SMSV are more perpendicular to the shell surface and results in most of the P domain dimer interactions to be mediated by the outermost P2 domain. The authors suggested that this inherent flexibility might increase antigenic diversity while maintaining the same domain organization.

37 Abstract The caliciviruses are by far the major cause of non-bacterial gastroenteritis, highly infectious, and have a rapid and severe onset of symptoms. Studies on this family of viruses have been hampered by the lack of animal model and tissue culture system. However, recent advances in protein expression systems and the development of a mouse norovirus animal model has led to rapid advances in our understanding of these viruses with regard to structure and the host immune response.

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Cell entry by non-enveloped viruses by Amy Odegard, Manidipa Banerjee, John E. Johnson (auth.), John E. Johnson (eds.)


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