C.-A. Andreae (auth.), Professor C. Prys-Roberts, Professor's Cardiovascular Measurement in Anaesthesiology PDF

By C.-A. Andreae (auth.), Professor C. Prys-Roberts, Professor M. D. Vickers (eds.)

ISBN-10: 3540117199

ISBN-13: 9783540117193

ISBN-10: 3642686907

ISBN-13: 9783642686900

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Extra info for Cardiovascular Measurement in Anaesthesiology

Sample text

CONC. 0144 I[MIN] 0;---~--r-~~-'--~---r--~--~ o 80 120 180 240 3 r. HIN END TIDAL CONC. 2 80 120 180 240 HIN Fig. 7. Comparison of measured and fitted end-tidal enflurane concentrations. The measured inspired concentrations are depicted in the upper part Table 2. Mean pharmacokinetic data for enflurane referring toa mean analysis time of 215 min for a group of 10 patients. D. 2 (273) 60 ± 31 (234) References 1. Colbrun WA, Shen D, Gilbaldi M (1976) Pharmacokinetic aralysis of drug concentration data obtained during repetitive drug administration.

D. The ratio {j/k lO indicates that on average 24% of the drug is present in the central compartment and available for elimination at any time. 83 which indicates a rapid equilibration between the deep peripheral and the central compartments. 53) could be the rate-limiting step in the elimination of alfentanil. The short analgesic effect is not related to the slow elimination of the drug with a t! {j of 94 min. It can only be attributed to the rapid displacement of the drug from the central and shallow peripheral compartments to the deep peripheral compartment.

The mean total plasma clearance was estimated at 456 ml/min. As only 63% of alfentanil is distributed to plasma in human blood, the mean total clearance in terms of whole blood was 730 ml/min. When looking at the evolution of the fraction of the initial alfentanil dose present in the different compartments as a function of time, it is apparent that maximal amounts of drug are already present in the shallow compartment 10 min after the alfentanil injection. On the other hand, the drug level reaches its maximum in the deep compartment only after one hour.

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Cardiovascular Measurement in Anaesthesiology by C.-A. Andreae (auth.), Professor C. Prys-Roberts, Professor M. D. Vickers (eds.)


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