Breast Cancer: Cellular and Molecular Biology - download pdf or read online

By Martha R. Stampfer, Jack C. Bartley (auth.), Marc E. Lippman, Robert B. Dickson (eds.)

ISBN-10: 1461289750

ISBN-13: 9781461289753

ISBN-10: 1461317339

ISBN-13: 9781461317333

Where do you start to appear for a up to date, authoritative article at the prognosis or administration of specific malignancy? The few normal oncology textual content­ books are often old-fashioned. unmarried papers in really expert journals are informative yet seldom complete; those are extra usually initial experiences on a really restricted variety of sufferers. definite common journals fre­ quently submit solid in-depth stories of melanoma themes, and released sym­ posium lectures are frequently the simplest overviews to be had. regrettably, those reports and supplementations seem sporadically, and the reader can by no means determine whilst a subject of particular curiosity may be coated. melanoma therapy and study is a chain of authoritative volumes which target to fulfill this desire. it really is an try and identify a serious mass of oncology literature protecting nearly all oncology issues, revised usually to maintain the assurance modern, simply to be had on a unmarried library shelf or via a unmarried own subscription. we've approached the matter within the following model. First, by means of divid­ ing the oncology literature into particular subdivisions equivalent to lung melanoma, genitourinary melanoma, pediatric oncology, and so on. moment, by means of asking eminent gurus in each one of those components to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor variety is roofed in a quantity showing usually and predictably, discussing present analysis, staging, markers, all types of therapy modalities, simple biology, and more.

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Additional resources for Breast Cancer: Cellular and Molecular Biology

Example text

A study of the c-myc locus in primary breast tumor DNAs from 121 patients revealed two types of genetic alterations [30]. In 32% of the tumors, there was a 2- to IS-fold amplification of the gene (Figure lA). The amplification was very likely specific for c-myc because the comas proto-oncogene, also located on chromosome 8, was not amplified [31]. In five other tumors, a rearrangement of c-myc was detected (Figure lA). Further analysis of one of these DNAs indicated that the breakpoint could be near the 3' end of c-myc exon 3.

Walen KH, Stampfer MR: Karyotypic changes in human mammary epithelial cells transformed in vitro. Submitted to Cancer Genet Cytogenet. 31. Bates SE, Valverius E, Salomon D, Stampfer M. Lippman ME. Dickson RB: Expression and estrogen regulation of transforming growth factor-a mRNA in human breast cancer. Proc Am Assoc Cancer Res 28: 233, 1987. 32. Wicha MS. Lowrie G, Kohn E, Bayavandoss P, Mahn T: Extracellular matrix promotes mammary epithelial growth and differentiation in vitro. Proc Natl Acad Sci USA 79: 32133217, 1982.

001) in this population compared with the unaffected population. At the present time, little is known about the molecular and biological consequences of the high frequency of rare c-H-ras-l alleles in breast cancer patients. In this context, Krontiris et al. [65], have claimed that deletion of the VTR in the EJ ras oncogene decreases its transforming potential 5- to 10-fold. This suggests that the VTR affects the regulation of c-H-ras-I expression. Horan Hand et ai. [67], have shown by immunohistochemical techniques that 60% of the primary breast tumors express ras p21.

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Breast Cancer: Cellular and Molecular Biology by Martha R. Stampfer, Jack C. Bartley (auth.), Marc E. Lippman, Robert B. Dickson (eds.)


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