By Desmond N. Carney, Adi F. Gazdar, Herbert K. Oie (auth.), F. Anthony Greco (eds.)
Lung melanoma is still a very tricky neoplasm to regard successfully. a wide a part of our loss of good fortune in facing those sufferers is said to our empiric healing makes an attempt. Slowly our simple knowing of the lung cancers is bettering and strategies have gotten to be had to permit us to higher comprehend the biology of those neoplasms. This quantity reports numerous components of curiosity in regard to the biologic habit and characteris of lung melanoma. tics Chapters care for the in vitro progress of small cellphone lung melanoma, the inves tigation of development components in human lung melanoma, the creation of mono clonal antibodies opposed to lung melanoma and the applying and strength use fulness of the human tumor cloning assay in lung melanoma administration. those avenues of research tend to identify a extra clinical foundation on which extra rational treatment might be designed. Carney and colleagues have verified a number of non-stop small phone lung melanoma cellphone strains of their laboratory. The amine precursor uptake and decar boxylation (APUD) homes of this neoplasm were proven through demonstrating the presence of neurosecretory granules and excessive degrees of the APUD enzyme L-dopa decarboxylase. additionally, a number of new markers were documented together with bombesin, creatine-kinase BB and neuron particular enolase. those tumor items besides others will be important serum markers in sufferers with small mobile lung cancer.
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Cancer Res 40:4356-4361, 1980. Sporn MB, Todaro GJ: Autocrine secretion and malignant transformation of cells. N Eng J Med 303:878-880, 1980. Todaro GJ, De Larco JE: Growth factors produced by sarcoma virus-transformed cells. Cancer Res 38:4147-4154, 1978. Todaro GJ, Fryling C, De Larco JE: Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc Nat! Acad Sci 77: 5258-5262, 1980. Sherwin SA, Minna JD, Gazdar AF, Todaro GJ: Expression of epidermal and nerve growth factor receptors and soft agar growth factor production by human lung cancer cells.
Composite picture representing the immune histochemical staining of necropsy slice of liver involved with metastatic SCLC. Serial section (A) H & E stain; (B) complete immune reaction minus monoclonal antibody 534F8; (C) complete immune reaction in the presence of antibody 534F8. The formalin fixed-paraffin embedded tissue specimen was processed for immune histochemical staining in the following manner: tissue sections were first deparaffinized in xylene and then exposed to a I % bovine serum albumin solution (with or without monoclonal antibody 534F8), followed by sequential incubations in normal horse sera, biotinylated horse antimous IgG, avidin-biotin-peroxidase complex (Vector Laboratories, Burlingame, CA).
Cancer 46:2062-2067, 1980. 25. Woo KB, Waalkes P, Abeloff MA, Ettinger DS, McNitt KL, Gehrke CW: Multiple biologic markers in the monitoring of treatment for small cell carcinoma of the lung: the use of serial levels of plasma CEA and carbohydrates. Cancer 48: 1633-1642, 1981 26. Hansen M: Clinical implications of ectopic hormone production in small cell carcinoma of the lung. Danish Med Bulletin 28: 221-236, 1981. 27. Greco FA, Hainsworth J, Sismani A, Richardson RL, Hande KR, Oldham RK: Hormone production and paraneoplastic syndromes.
Biology and Management of Lung Cancer by Desmond N. Carney, Adi F. Gazdar, Herbert K. Oie (auth.), F. Anthony Greco (eds.)