By Agata Polizzi, Domenica Taruscio (auth.), Lorenzo Emmi (eds.)
Behçet's syndrome can quite be thought of a distinct entity between ailments of the immune method for numerous purposes: It has particular gains and, uniquely one of the immune procedure pathologies, represents a hyperlink among autoimmune illnesses, systemic vasculitis, and autoinflammatory illnesses. furthermore, it truly is of curiosity to various experts, together with immunologists, rheumatologists, dermatologists, and ophthalmologists, and calls for a posh multidisciplinary process. Many elements have to be thought of in a syndrome that offers a large spectrum of indicators and for which the healing armamentarium is increasing considerably, with the improvement of recent remedies, no longer least the so-called biologics. This ebook bargains accomplished assurance of the illness via the various world’s top specialists in Behçet's syndrome from all of the appropriate specialties. Epidemiology, genetics, pathogenesis, organ process involvement, differential analysis, novel remedies, surgical administration, and analysis are only the various issues addressed. Behçet's Syndrome: From Pathogenesis to therapy could be a useful reference for a number of practitioners, researchers, and undergraduates or postgraduates attracted to immuno-rheumatology, dermatology, and infrequent diseases.
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Additional info for Behçet's Syndrome: From Pathogenesis to Treatment
Ann Rheum Dis 72:1510–1516 5 Infections, Autoimmunity, and Behc¸et’s Syndrome: What Liaison? 1 Immune Responses to Infections During the course of evolution, the immune system had to continuously shape and refine its mechanisms of defense against pathogens. In response to different microorganisms, specialized types of specific responses allow the recognition and elimination of infectious agents. Viruses, which grow within the infected cell, can be successfully eliminated only by killing their host cells by CD8 class I major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes, which recognize viral antigens synthesized within infected cells and present on their surface in the context of class I MHC molecules.
Nishikomori R, Usui T, Wu CY et al (2002) Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol 169:4388–4398 68. Mathur AN, Chang HC, Zisoulis DG et al (2007) Stat3 and Stat4 direct development of IL17-secreting Th cells. J Immunol 178:4901–4907 69. Sun LD, Cheng H, Wang ZX et al (2010) Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
Furthermore, NapA is able to stimulate monocyte expression of IL-23, IL-6, TGF-b, and IL-1-b, key cytokines for Th17 cell differentiation. Since Th1 an Th17 cells dominate the immune response in the synovial fluid of patient with LA, it has been suggested the possibility that such T cells are indeed effectors of an autoimmune process [46, 48–50]. In accordance with the fact that both Th1 and Th17 cells are involved in LA pathogenesis, there is a prominence of some chemokines crucial for their recruitment into the synovial fluids of patients, such as CXCL10, specific for Th1 cells, and CCL2, specific for both Th1 and Th17 cells [51, 52].
Behçet's Syndrome: From Pathogenesis to Treatment by Agata Polizzi, Domenica Taruscio (auth.), Lorenzo Emmi (eds.)