By Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian Goldman (eds.)
Adhesion performs an enormous position within the bacterial way of life. micro organism can adhere to natural and inorganic surfaces, to one another, and naturally to host cells in the course of pathogenesis.
The concentration of this ebook is: how are such adhesion phenomena most sensible studied? Microbial genetics experiments have drastically greater our wisdom of what bacterial components are occupied with adhesion. for various purposes, notwithstanding, biochemical and structural biology wisdom of the molecular interactions interested in adhesion are constrained. One serious problem has been an absence of interdisciplinary examine and knowing within the box. at the one hand, the microbiologists lack precise wisdom of the biophysical probabilities and feature restricted entry to the usually dear instrumentation concerned whereas nevertheless, the specialists in those equipment often do not need entry to the organic fabrics, nor do they unavoidably comprehend the organic inquiries to be replied. the aim of this booklet is hence to beat this hole in conversation among researchers in biology, chemistry and physics and to exhibit the numerous methods and capability to enquire bacterial adhesion. we are hoping to stimulate new and ground-breaking research.
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Additional resources for Bacterial Adhesion: Chemistry, Biology and Physics
However, all fimbrial adhesins characterised so far in Salmonella exhibit lectin-like functions. , 2008) and the best-studied fimbrial adhesin FimH, which is encoded by the fim operon, is highly specific for mannose residues. , 2001). Fim fimbriae are members of the type 1 fimbriae family, which are characterised by mannose-sensitive hemagglutination and mannose-sensitive binding to host cells (Duguid, 1959). , 1980). , 1999). FimH, which represents the tip of the fimbriae, is responsible for the varying binding properties on the host cell.
2002). , 2003, 2000). , 2003). However, infections of pigs with an shdA mutant did not indicate a role for ShdA in virulence in this model, as ShdA was not required for persistence or prolonged shedding in infected pigs. This divergence again underlines the notion that adhesins of S. , 2006). , 1999). , 2005), but heterologous expression resulted in the presence of MisL on the outer membrane of S. Typhimurium. , 2002). , 2007). Expression of misL is also likely to occur in vivo, as mice infected with S.
Infect Immun 78:5233–5243 Koretke KK, Szczesny P, Gruber M, Lupas AN (2006) Model structure of the prototypical nonfimbrial adhesin YadA of Yersinia enterocolitica. J Struct Biol 155:154–161 Kukkonen M, Suomalainen M, Kyllönen P, Lähteenmäki K, Lång H, Virkola R, Helander IM, Holst O, Korhonen TK (2004) Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica. Mol Microbiol 51:215–225 Lathem WW, Price PA, Miller VL, Goldman WE (2007) A plasminogen-activating protease specifically controls the development of primary pneumonic plague.
Bacterial Adhesion: Chemistry, Biology and Physics by Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian Goldman (eds.)