By Christian Weber, Oliver Soehnlein
In fresh years, the certainty of the pathophysiological procedures of atherosclerosis, a prolonged inflammatory sickness of the vessel wall being the top reason for mortality in business international locations, has vastly elevated. The feasibility of translating such wisdom to novel healing ways is at the moment being explored at numerous degrees. This e-book highlights advances in atherosclerosis and hyperlinks those to appropriate healing options. It compiles and information state-of-the-art learn in cardiovascular medication from across the world well known authors.
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Additional resources for Atherosclerosis : treatment and prevention
2007). Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice, Arterioscler. Thromb. Vasc. Biol. 27, pp. 373–379. 64. , Gao, J. , Murphy, P. , and Mallat, Z. (2005). 25 26 Chemokines and Their Receptors as Therapeutic Targets in Atherosclerosis Chemokine receptor CCR1 disruption in bone marrow cells enhances atherosclerotic lesion development and inflammation in mice, Mol. Med. 11, pp. 16–20. 65. , and Littman, D. R. (2003). Blood monocytes consist of two principal subsets with distinct migratory properties, Immunity 19, pp.
In contrast to the rabbit model, the expression of MIF increases during plaque progression in human atherosclerosis . Whereas in arteries without atherosclerotic findings or with type I (initial) lesions without macrophage infiltration, MIF was only detected in a small number of endothelial cells and SMCs, the number of MIF-expressing cells was significantly higher in fatty-streak (type II) and advanced inflammatory lesions . MIF expression was most prominent in vicinity to the acellular lipid core, especially in macrophages.
Koenen, R. , Kungl, A. , and Weber, C. (2010). A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/ reperfusion injury in mice, J. Am. Coll. Cardiol. 56, pp. 1847–1857. 80. , Liu, L. , Sun, Y. , Bartee, M. , Esko, J. , and Lucas, A. R. (2010). Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection, Plos One 5, pp. e10510. 81. , and Davidson, M.
Atherosclerosis : treatment and prevention by Christian Weber, Oliver Soehnlein