Appetite Control by Elizabeth C. Cottrell, Julian G. Mercer (auth.), Hans-Georg PDF

By Elizabeth C. Cottrell, Julian G. Mercer (auth.), Hans-Georg Joost (eds.)

ISBN-10: 3642247156

ISBN-13: 9783642247156

ISBN-10: 3642247164

ISBN-13: 9783642247163

The quantity ‘Appetite keep an eye on’ offers a entire description of the mechanisms controlling nutrition consumption, and thereby strength stability, within the mammalian organism. over the last decade, learn during this region has produced a awesome wealth of knowledge and has characterised the functionality of diverse peptides, transmitters, and receptors in urge for food keep an eye on. disorder of those circuits ends up in weight problems, a becoming well-being main issue. notwithstanding, the plethora of mechanistic info is in marked contrasts to a virtually entire loss of anti-obesity medications that meet the security criteria required for the continual treatment of morbid weight problems. as a result, ongoing study goals to spot extra goals and brokers for a pharmacological intervention. therefore, the mechanisms of urge for food keep watch over in addition to all brokers interfering with its regulate are of substantial functional interest.

The authors of the quantity are exclusive scientists who're best specialists within the box, and who've contributed vital, unique info to our knowing of the mechanisms of urge for food keep watch over. they've got really diversified medical backgrounds and, jointly, they signify all suitable disciplines. Thereby, the subjects are offered from various issues of view, now not completely from that of pharmacology and neuroendocrinology. hence, the amount addresses all scientists who're attracted to the sphere of weight problems learn and the pathophysiology of urge for food control.

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4 NPY and Adiposity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 NPY and Energy Expenditure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Problems with the Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Potential Clinical Applications of NPY . . . . . . . . . . . . .

Woods Ammar and colleagues (Ammar et al. 2000) when they observed that NPY infusion could actually decrease food intake in some social situations. Using a different approach (Drazen et al. 2005), we found that rats trained to anticipate receiving NPY at a specific time of day learn to eat more at that time even when no NPY is administered. , there is compelling evidence that rather than initiating eating per se, NPY acts upon circuits that prepare and thus enable the animal to consume large meals.

7 Potential Clinical Applications of NPY . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 27 29 30 31 32 35 36 36 Abstract When administered into the brain, NPY acts at Y1 and Y5 receptors to increase food intake.

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Appetite Control by Elizabeth C. Cottrell, Julian G. Mercer (auth.), Hans-Georg Joost (eds.)


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