Anatomy of a Scientific Discovery: The Race to Find the - download pdf or read online

By Jeff Goldberg

ISBN-10: 1626361932

ISBN-13: 9781626361935

In past due 1973, scientists John Hughes and Hans Kosterlitz spent the vast majority of their time in an underfunded, vague, and cramped laboratory in Aberdeen, Sweden. whereas engaged on the brains of pigs, the duo chanced on a nonaddictive narcotic chemical that they was hoping to later locate in human brains. in the event that they may perhaps isolate this chemical in people, might be they can have the option to aid the realm start to heal itself. Hughes and Kosterlitz’s learn could unavoidably cause them to become aware of endorphins, the body’s personal traditional morphine and the chemical that makes it attainable to believe either discomfort and pleasure.

Announcing their findings to the clinical international thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists around the globe have been swiftly interpreting the human mind and its endorphins. In many years’ time, they might use the team’s preliminary learn to hyperlink endorphins to drug habit, runner’s excessive, urge for food regulate, sexual reaction, and psychological health problems akin to melancholy and schizophrenia.

In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives ahead of, in the course of, and after their old and clinical step forward. He additionally takes a glance on the higher photo, revealing the brutal festival among drug businesses to discover how to take advantage of this huge discovery.

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John Hughes half-jokingly claimed that he had acquired his own Cortina so as not to keep having to refuse Kosterlitz’s offers of a lift. Kosterlitz was amazingly energetic for a septuagenarian. Alan North, an electrophysiologist in the Unit—who was a mountain-climbing enthusiast—would often meet him on the way to work, and the two would race up the spiraling staircase to the third-floor labs. Somehow, Kosterlitz always managed to keep up with the younger, more athletic man, even though he took several minutes in the privacy of his office to recover from the workout.

Goldstein believed in high technology and was familiar with the battery of new methods, employing radioactive tracers and supersensitive detection procedures, which were enabling researchers for the first time to determine how drugs worked in the body on the molecular level. He was hardly shy about evaluating the impact of his work on the field: “I thought, from the beginning, that pharmacology was a discipline in transition,” he once said, “that it was moving away from tissue preparations like the ileum to a biochemical footing.

Opiates were strong but addictive; aspirin was safe but not strong enough to effectively treat migraine, arthritis, or the little understood syndrome of chronic pain. There was a good chance that substance X might provide a unique alternative. ” If so, its commercial potential was vast, in the hundreds of millions of dollars—which was not to discount the purely scientific value of substance X. If, as Hughes suspected, substance X was part of a fundamental mechanism in the brain regulating the perception of pain, it was possible that it might capture the attention of the Nobel prize committee, and it was probable that competing researchers were going to be very, very interested as well.

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Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine by Jeff Goldberg


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