By National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Human Embryonic Stem Cell Research Advisory Committee
In 2005, the nationwide Academies published the record guidance for Human Embryonic Stem telephone examine, which provided a standard set of moral criteria for a box that, end result of the absence of accomplished federal investment, used to be missing nationwide criteria for research.
In order to maintain the ideas brand new, given the fast velocity of clinical advancements within the box of stem cellphone learn, the Human Embryonic Stem mobilephone learn Advisory Committee was once demonstrated in 2006 with aid from The Ellison clinical origin, The Greenwall starting place, and the Howard Hughes clinical Institute.
As it did in 2007, the Committee pointed out concerns that warranted revision, and this ebook addresses these concerns in a moment set of amendments. most significantly, this ebook addresses new medical advancements in reprogramming of somatic cells to pluripotency by means of including a brand new part and revising different proper sections of the Guidelines.
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Extra info for 2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research
Particular attention should be paid to at least three factors: the extent to which the 35 36 Appendix A implanted cells colonize and integrate into the animal tissue; the degree of differentiation of the implanted cells; and the possible effects of the implanted cells on the function of the animal tissue. 3(c)]: (1) E xperiments that involve transplantation of hPS cells into human blastocysts. (2) Research in which hPS cells are introduced into nonhuman primate embryos, pending further research that will clarify the potential of such introduced cells to contribute to neural tissue or to the germ line.
Morula—A solid mass of 16–32 cells that resembles a mulberry and results from the cleavage (cell division without growth) of a zygote (fertilized egg). Mouse embryonic fibroblast (MEF)—Cells used as feeder cells in culturing pluripotent stem cells. Multipotent—Capable of differentiation into a limited spectrum of differentiated cell types. Neural stem cell (NSC)—A stem cell found in adult neural tissue that can give rise to neurons, astrocytes, and oligodendrocytes. Nuclear transfer (NT)—Replacing the nucleus of one cell with the nucleus of another cell.
Pseudopregnant—Refers to a female primed with hormones to accept a blastocyst for implantation. Somatic cell—Any cell of a plant or animal other than a germ cell or germ cell precursor. Somatic cell nuclear transfer (SCNT)—The transfer of a cell nucleus from a somatic cell into an egg (oocyte) whose nucleus has been removed. Stem cell—A cell that has the ability to divide for indefinite periods in vivo or in culture and to give rise to specialized cells. Appendix B Teratoma—A tumor composed of tissues from the three embryonic germ layers.
2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research by National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Human Embryonic Stem Cell Research Advisory Committee